The Pyridine Nucleotide Coenzymes
نویسندگان
چکیده
منابع مشابه
Binding of pyridine nucleotide coenzymes to the beta-subunit of the voltage-sensitive K+ channel.
The beta-subunit of the voltage-sensitive K(+) (K(v)) channels belongs to the aldo-keto reductase superfamily, and the crystal structure of K(v)beta2 shows NADP bound in its active site. Here we report that K(v)beta2 displays a high affinity for NADPH (K(d) = 0.1 micrometer) and NADP(+) (K(d) = 0.3 micrometer), as determined by fluorometric titrations of the recombinant protein. The K(v)beta2 a...
متن کاملPyridine coenzymes of subcellular tissue fractions.
The levels of pyridine nucleotides in tissues have been the subject of a large number of reports. Much interest has been focused on the ratios of oxidized to reduced coenzymes in different pathological conditions (1). Recently, Glock and McLean (2) have reported the important observation that reduced TPN is present in whole rat liver in comparatively large amounts, whereas the concentration of ...
متن کاملDifferential regulation of voltage-gated K+ channels by oxidized and reduced pyridine nucleotide coenzymes.
The activity of the voltage-sensitive K+ (Kv) channels varies as a function of the intracellular redox state and metabolism, and several Kv channels act as oxygen sensors. However, the mechanisms underlying the metabolic and redox regulation of these channels remain unclear. In this study we investigated the regulation of Kv channels by pyridine nucleotides. Heterologous expression of Kvalpha1....
متن کاملHighly reduced analogues of the pyridine nucleotide coenzymes. Synthesis of tetrahydro- and hexahydronicotinamide adenine dinucleotides and certain of their derivatives.
Catalytic hydrogenation of the appropriate pyridine nucleotide coenzymes and their derivatives over palladium supported on barium carbonate in aqueous solution has yielded the following representatives of two novel series of coenzyme analogues: tetrahydronicotinamide adenine dinucleotide, tetrahydronicotinamide mononucleotide, 3-acetyltetrahydropyridine adenine dinucleotide, hexahydronicotinami...
متن کاملPyridine Nucleotide Transhydrogenase
established unequivocally that either a hydrogen or electron transfer was involved in this reaction. The possibility of a transfer of the monoester phosphate group or an exchange of reduced and oxidized nicotinamidecontaining moieties (nucleoside, nucleotide, etc.) was ruled out by this and other experiments. There still remained, however, the problem of distinguishing experimentally between th...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1983
ISSN: 0014-5793
DOI: 10.1016/0014-5793(83)81081-3